台灣南部某職場工作者低密度脂蛋白膽固醇過高之盛行率及相關因子探討

Prevalence of Elevated Low-density Lipoprotein Cholesterol among Young Workers at a Factory in Southern Taiwan

林志遠(Chih-Yuan Lin) ； 王建楠(Jian-Nan Wang) ； 蘇世斌(Shih-Bin Su)

《台灣家庭醫學雜誌》 18卷4期 (2008/12) Pp. 221-232

https://doi.org/10.7023/TJFM.200812.0221

摘要

Purpose: Dyslipidemia and elevated low-density lipoprotein cholesterol (LDL-C) have been identified as risk factors for atherosclerosis and cardiovascular disease. The aim of this study was to evaluate the prevalence of and factors related to elevated LDL-C among young workers in southern Taiwan.
Materials & Methods: We conducted a cross-sectional study by analyzing the database from the 2007 annual health examination of a company in southern Taiwan. Anthropometric measurements, sex, age, serum lipid profile, blood pressure, glutamic-pyruvic transaminase (GPT), and fasting glucose were recorded. Patients were divided into 4 categories according to their level of LDL-C: ＜130 mg/dL, 130-159 mg/dL, 160-189 mg/dL, ＞190 mg/dL; and elevated LDL-C was defined ＞130 mg/dL.
Result: A total of 16,123 workers, 7,556 (46.9%) men and 8,567 (53.1%) women, were recruited. The mean serum level of LDL-C in the men (115.6±29.4 mg/dL) was higher than that in the women (104.1±27.0 mg/dL) ( p＜0.001). The overall prevalence of elevated LDL-C was 21.3%. The older men with higher BMI and blood pressure, and abnormal fasting glucose, GPT, triacylglycerol (TG), and high-density lipoprotein cholesterol (HDL-C) had a higher prevalence of elevated LDL-C. After adjusting for age, sex, BMI, blood pressure, fasting glucose, GPT, TG, and HDL-C, male sex, older age, higher BMI, higher blood pressure, impaired fasting glucose, and abnormal GPT, TG, and HDL-C were independent risk factors of elevated LDL-C.
Conclusion: Elevated LDL-C was prevalent, and its risk factors were similar to those for cardiovascular disease in this young working population.

並列摘要

Purpose: Dyslipidemia and elevated low-density lipoprotein cholesterol (LDL-C) have been identified as risk factors for atherosclerosis and cardiovascular disease. The aim of this study was to evaluate the prevalence of and factors related to elevated LDL-C among young workers in southern Taiwan.
Materials & Methods: We conducted a cross-sectional study by analyzing the database from the 2007 annual health examination of a company in southern Taiwan. Anthropometric measurements, sex, age, serum lipid profile, blood pressure, glutamic-pyruvic transaminase (GPT), and fasting glucose were recorded. Patients were divided into 4 categories according to their level of LDL-C: ＜130 mg/dL, 130-159 mg/dL, 160-189 mg/dL, ＞190 mg/dL; and elevated LDL-C was defined ＞130 mg/dL.
Result: A total of 16,123 workers, 7,556 (46.9%) men and 8,567 (53.1%) women, were recruited. The mean serum level of LDL-C in the men (115.6±29.4 mg/dL) was higher than that in the women (104.1±27.0 mg/dL) ( p＜0.001). The overall prevalence of elevated LDL-C was 21.3%. The older men with higher BMI and blood pressure, and abnormal fasting glucose, GPT, triacylglycerol (TG), and high-density lipoprotein cholesterol (HDL-C) had a higher prevalence of elevated LDL-C. After adjusting for age, sex, BMI, blood pressure, fasting glucose, GPT, TG, and HDL-C, male sex, older age, higher BMI, higher blood pressure, impaired fasting glucose, and abnormal GPT, TG, and HDL-C were independent risk factors of elevated LDL-C.
Conclusion: Elevated LDL-C was prevalent, and its risk factors were similar to those for cardiovascular disease in this young working population.

並列關鍵字

LDL-C ； dyslipidemia ； cardiovascular disease

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