健康生活型態介入對於女性高膽固醇血症及其他代謝症候群風險因子之影響

The Effect of Lifestyle Modification on Hypercholesterolemia and Other Risk Factors for Metabolic Syndrome in Females

陳暉明(Hui-Ming Chen) ； 王聖棻(Sheng-Fen Wang) ； 黃志芳(Chih-Fang Huang) ； 周騰達(Tang-Tat Chau) ； 辜美安(Malcolm Koo)

《台灣家庭醫學雜誌》 20卷4期 (2010/12) Pp. 192-202

https://doi.org/10.7023/TJFM.201012.0192

摘要

Background: Hypercholesterolemia and metabolic syndrome are increasingly threatening to the health of the Taiwanese people. Lifestyle modification remains the primary treatment strategy for these conditions. We investigated the effect of lifestyle modification on hypercholesterolemia and other risk factors for metabolic syndrome by utilizing a nine-month lifestyle modification program.Methods: The present study used a prospective design. Female subjects afflicted with hypercholesterolemia or risk factors for metabolic syndrome were selected from among the participants in the January 2005 adult health examination in Dalin township of Chiayi county in Taiwan. The intervention group consisted of 27 females who completed the 9-month lifestyle modification program. The control group consisted of 27 age-matched (at 5-year intervals) females who did not participate. Non-parametric tests were used to compare the differences in adult health examination data between the intervention and control groups. This data included body weight, body mass index, waist circumference, number of risk factors for metabolic syndrome, blood pressure, and levels of blood cholesterol, blood triglycerides, and blood glucose.Results: Significant differences were observed in the pre- and post-intervention values between the intervention and control groups. Change in the median value of waist circumference was -1cm in the intervention group and +1cm in the control group (p＜0.001). The median values of diastolic pressure decreased 7 mmHg in the intervention group but increased 2 mmHg in the control group (p=0.001). The median values of total cholesterol decreased 17 mg/dL in the intervention group but increased 6 mg/dL in the control group (p=0.004). The median values of triglycerides increased 2 mg/dL in the intervention group but increased 24 mg/dL in the control group (p=0.040). The median values of blood glucose decreased 9 mg/dL in the intervention group but increased 4 mg/dL in the control group (p=0.001).Conclusions: The lifestyle modification program significantly reduced the levels of cholesterol and other risk factors for metabolic syndrome in females.

並列摘要

Background: Hypercholesterolemia and metabolic syndrome are increasingly threatening to the health of the Taiwanese people. Lifestyle modification remains the primary treatment strategy for these conditions. We investigated the effect of lifestyle modification on hypercholesterolemia and other risk factors for metabolic syndrome by utilizing a nine-month lifestyle modification program.Methods: The present study used a prospective design. Female subjects afflicted with hypercholesterolemia or risk factors for metabolic syndrome were selected from among the participants in the January 2005 adult health examination in Dalin township of Chiayi county in Taiwan. The intervention group consisted of 27 females who completed the 9-month lifestyle modification program. The control group consisted of 27 age-matched (at 5-year intervals) females who did not participate. Non-parametric tests were used to compare the differences in adult health examination data between the intervention and control groups. This data included body weight, body mass index, waist circumference, number of risk factors for metabolic syndrome, blood pressure, and levels of blood cholesterol, blood triglycerides, and blood glucose.Results: Significant differences were observed in the pre- and post-intervention values between the intervention and control groups. Change in the median value of waist circumference was -1cm in the intervention group and +1cm in the control group (p＜0.001). The median values of diastolic pressure decreased 7 mmHg in the intervention group but increased 2 mmHg in the control group (p=0.001). The median values of total cholesterol decreased 17 mg/dL in the intervention group but increased 6 mg/dL in the control group (p=0.004). The median values of triglycerides increased 2 mg/dL in the intervention group but increased 24 mg/dL in the control group (p=0.040). The median values of blood glucose decreased 9 mg/dL in the intervention group but increased 4 mg/dL in the control group (p=0.001).Conclusions: The lifestyle modification program significantly reduced the levels of cholesterol and other risk factors for metabolic syndrome in females.

並列關鍵字

lifestyle intervention ； metabolic syndrome ； waist circumference ； hypertension ； dyslipidemia

參考文獻

Grundy, SM(2008).Metabolic syndrome pandemic.Arterioscler Thromb Vasc Biol.28,629-36.

陳建仁、游山林、白其卉()。,未出版。

Grundy, SM,Hansen, B,Smith, SC, Jr.,Cleeman, JI,Kahn, RA,American Heart Association,National Heart, Lung, and Blood Institute,American Diabetes Association(2004).Clinical management of metabolic syndrome: report of the American Heart Association/National Heart, Lung, and Blood Institute/American Diabetes Association conference on scientific issues related to management.Circulation.109,551-6.

Lichtenstein, AH,Ausman, LM,Jalbert, SM(2002).Efficacy of a Therapeutic Lifestyle Change/Step 2 diet in moderately hypercholesterolemic middle-aged and elderly female and male subjects.J Lipid Res.43,264-73.

Kingsley, RG,Wilson, GT(1977).Behavior therapy for obesity: a comparative investigation of long-term efficacy.J Consult Clin Psychol.45,288-98.