- 期刊
病例報告：貓小腸黏膜相關淋巴組織淋巴瘤
Case Report: Mucosal Associated Lymphoid Tissue Lymphoma (MALToma) of Small Intestine in a Cat
摘要
病畜為一隻十二歲雌性波斯貓，一年前出現繞圈、斜頸等神經症狀及半年前有呼吸急促病史，死亡前三天食慾廢絕。血液生化學檢查，ALT、AST略高及白蛋白輕微下降；X光影像學檢查，肺實質出現棉絮狀肺炎影像，病理剖檢發現小腸後段黏膜面增厚；且有多處深褐色的小潰腸灶；顯微鏡下，黏膜層至黏膜下層發現大量的腫瘤性淋巴球浸潤，淋巴細胞突破黏膜肌層至黏膜層，且侵入腸管腺窩（crypts）上皮破壞正常的腺體結構，腫瘤細胞形態上類似淋巴球，大小一致且有絲分裂現象少，經cytokeratin免疫組織化學染色及PAS組織化學染色，證實該淋巴瘤細胞侵犯基底膜及浸潤於腸管腺窩上皮。其餘病變包括胸腔內有淡黃色清澈的胸水，肺臟有散發的針尖狀膿瘍病灶；心臟左右心室明顯擴張且右心室肌壁變薄，左心的腱索變粗、短與心內膜壁互相連接。依據小腸的組織病理學特徵性變化，診斷為小腸黏膜相關淋巴組織淋巴瘤。
並列摘要
A 12-year-old spayed female Persian cat was referred to the National Taiwan University Veterinary Hospital with a history of nervous and respiratory symptoms, with three days anorexia before death. Serum biochemical examination revealed a slight increased alanine transaminase (ATL) and aspartate aminotransferase (AST) activity, and hypoalbuminemia. Thoracic radiographs showed a radiopaque, cotton-like image in the pulmonary parenchyma. At postmortem examination, the thickening of intestinal wall of jejuno-ileal junction was noted and mucosa had multifocal ulcerations. Histopathologically, a typical Iymphoepithelial lesion with massive infiltration of lymphoid cells extending from the submucosa to mucosa in small intestine is observed. The destruction of basement membrane of the crypts and crypt infiltration by neoplastic cells are demonstrated by cytokeratin immunocytochemistry and PAS stain. Tumor cells are uniform in size, and mitotic figures are rarely seen. Additional changes included in excessive serosanguineous effusion in the thoracic cavity and microabscesses in bilateral lungs and heart dilation. Based on the characteristic features, mucosal associated lymphoid tissue lymphoma (MALToma) in the small intestine is diagnosed in this cat.