在台灣利用假性狂犬病gE缺損活毒疫苗控制假性狂犬病之效益

Efficacy of Pseudorabies Control Using a Live PR gE-deleted Vaccine in Taiwan

吳明勳(Ming-Hsun Wu) ； 廖俊旺(Jiunn-Wang Liao) ； 宣詩玲(Shih-Ling Hsuan) ； 簡茂盛(Maw-Sheng Chien) ； 林正忠(Cheng-Chung Lin) ； 李維誠(Wei-Cheng Lee)

《臺灣獸醫學雜誌》 33卷3&4期 (2007/12) Pp. 203-210

https://doi.org/10.7009/TVJ.200712.0203

摘要

本試驗利用假性狂犬病(Pseudorables, PR)gE缺損活毒疫苗在兩個高PRgE抗體陽性率之－貫飼養場（CS及BH牧場），以加強及大規模免疫方式對全場之母豬、女豬及肉豬進行定期完整之免疫措施，並視各族群以95%檢出機率定期採血進行gE抗體檢測。兩場之肉豬及女豬在落實完整免疫措施後6~12月內，gE抗體均由高陽性率轉為陰性，並持續至第二年底，但經產母豬在免疫一年後仍維持高陽性率。日增重及降低肉豬之死亡率在CS牧場有所改善，BH牧場未進行分析。以上結果顯示PRgE缺損活毒疫苗在完整免疫措施下，能有效控制本病在肉豬及女豬之流行，進而達到場內清浮的目標。

關鍵字

假性狂犬病 ； PR gE缺損活毒疫苗 ； 預防

並列摘要

The aim of this experiment was to evaluate the efficacy of a live gE-deleted PR vaccine used in PR control in two farrow-to-finish pig farms (farm CS and BH) with high PR antibody prevalence. An intensive and massive vaccination program using a live gE-deleted PR vaccine had been implemented on fattening pigs, gilts, and sows. Blood samples were collected for gE antibody detection dependent on PR prevalence and 95% possibility. Six to twelve months after the intensive vaccination, the prevalence of gE antibody in fattening pigs and gilts had become negative. However, high gE antibody prevalence of sows did not show improvement after the intensive vaccination program. The slight improvement of daily weight gain and decrease in mortality after the intensive vaccination was also noted in Farm CS. There was no data available in farm BH. According to these results, we suggest that an intensive and massive vaccination strategy using the live gE-deleted PR vaccine could be efficient in protecting finisher s and gilts from PR infection and ultimately achieve the goal of disease eradication in farm.

並列關鍵字

PR ； Live PRV gE-deleted vaccine ； Prevention