傳染性腹膜炎發病貓之同居貓隻其冠狀病毒排毒監測之研究

Shedding of Feline Coronavirus in the Cats Living in the Same Household with Feline Infectious Peritonitis Cats

謝明偉(Ming-Wei Hsieh) ； 闕玲玲(Ling-Ling Chueh) ； 蘇璧伶(Bi-Ling Su)

《臺灣獸醫學雜誌》 34卷3期 (2008/09) Pp. 170-176

https://doi.org/10.7009/TVJ.200809.0170

摘要

貓冠狀病毒(Feline coronavirus; FCoV)依其致病性可區分為貓傳染性腹膜炎病毒(Feline infectious peritonitis virus；FIPV)及貓腸道型冠狀病毒(Feline enteric coronavirus；FECV)。前者會引起貓傳染性腹膜炎(FIP)造成貓隻死亡，而後者則僅引起輕微之消化道症狀，目前FIPV被認為乃由FECV之突變所致。為了解本省貓隻貓冠狀病毒之感染情形，本實驗藉由反轉錄巢式聚合酶鏈鎖反應(RT-nPCR)，針對臨床疑似感染病例進行檢測。經確認為FIP之發病貓而同時生活於多貓家庭者，再進一步針對其同居貓隻之血液與糞便或直腸拭子進行長期監測。在五個多貓家庭的分析結果中發現，與FIP發病貓同居之21隻貓，其中部分貓隻在該家庭出現FIP發病貓同時，亦呈現短期間的病毒血症，然這些貓隻臨床上皆屬健康未出現FIP的症狀。在監測期間，這些生活在多貓家庭大部分的貓隻，持續排毒長達12至18個月。綜合以上發現可知台灣貓隻族群內存有冠狀病毒持續感染的問題，其與FIP發病間的相關性仍待進一步之釐清。持續監測貓族群的排毒現象，臨床上可應用於篩選及隔離慢性排毒貓隻，建立無冠狀病毒感染貓隻族群。

關鍵字

貓冠狀病毒 ； 貓傳染性腹膜炎 ； 多貓家庭 ； 排毒監測

並列摘要

Feline coronavirus (FCoV) can cause two distinct diseases known as feline infectious peritonitis (FIP) and mild enteritis. FIP is an immune mediated lethal disease. The virus that causes FIP is currently believed to be originated from the mutation of virus that causes enteritis. In order to understand the persistence of FCoV infection in cats living in multiple-cat households that had a confirmed FIP case, clinical specimens including body effusion, blood, feces/rectal swabs were collected. RT-nPCR targeted on the 3-UTR of FCoV genome was applied for detection of FCoV. Six FIP cats from 5 individual multiple-cat households and 21 cats living in the same household were monitored. Persistently shedding of FCoV for at least 12~18 months was observed in most of the test cats. Irrespective of a period of viremia once observed in some of the non-FIP cats, all the 21 cats were clinical healthy throughout the entire examination period.

並列關鍵字

feline corona virus ； feline infectious peritonitis ； multiple-cat household ； virus shedding