Five Labrador retriever puppies were whelped by a 3-year-old bitch. Three of the puppies displayed alopecia, erythema, scale, crust, ulceration, as well as nodular and pustular lesions, on the tails, limbs, and abdomens at 3 weeks of age, however, the other two puppies appeared normal. No significant parasites, bacteria, and fungi were found on Scotch tape strip examination. The diseased puppies were much improved after three to four weeks of treatment with oral corticoidsteroid, vitamin B6, Coatex pump (VetPlus), and topical therapy with ChlorhexiDerm shampoo (DVM) and Flarzon ointment.