Bone marrow suppression is common with cancer patients, when they are treated with high dose chemotherapy or radiotherapy. Autogenetic stem cell transplantation is an usual rescue method to shorten the period of bone marrow agenesis, to decrease infection rate, and hemorrhage complications. This article described the nursing experience of a patient with lymphoma who was going to receive auto genetic peripheral stem cell transplantation. She lacked the knowledge of bone marrow suppression, stem cell transplantation, with her unwillingness for admission and infection during immune suppression period. Apart from supplying nursing instructions to intensity her knowledge about stem cell transplantation, about infection and hemorrhage prevention, the author tried to understand the inner psychological problems of this patient and to give the patient a hand to relieve her anxiety and weakness. The author also helped the patient to decrease the complication while collecting autogenetic stem cell from peripheral blood and to keep her comfortable physiologically and psychologically.