In this study, we report the experience of providing nursing care for an adult patient with short bowel syndrome who underwent small intestine transplantation. We used Orem's theory to perform the nursing evaluation. During the surgical period, the patient experienced perioperative anxiety, had potential risks of perioperative positioning injury and wound infection, lacked knowledge of the condition, and had other issues. During the preoperative period, nurses provided assistance and implemented educational measures. Likewise, visiting, listening, and accompanying the patient helped to establish a positive relationship between the patient and nurses and alleviate the patient's anxiety. To maintain patient safety and prevent unnecessary injury during the surgical period, systemic siliceous fat pads and cotton were used to protect the skin. Before surgery, we administered antibiotics and followed the principle of asepsis to prevent potential wound infection. During surgery, we pasted a waterproof film and plastic wrap around the surgical site to maintain skin integrity and prevent skin infiltration. Patients and caregivers were provided with an explanation regarding the identification of acute rejection symptoms after transplantation, the purpose of intestinal fistula retention, and home care.