This article is a nursing experience of a 17-year-old high school girl diagnosed with tuberculosis. The nursing period was from August 2 to September 1, 2019. Data were collected and inducted to the domain of physiology, psychology, and social culture. The identified nursing problems were pain, social isolation, and anxiety. The nursing process included adjusting pain relief methods, interacting with peers through audiovisual devices, providing mental support, and home care health education. When the client stated her worries about returning to school, a guided discussion was conducted on how to face the situation of expelling out of the group or infecting others. Telephone follow-up after discharge confirmed that the client has accommodated the new school life. The care of adolescent diagnosed with tuberculosis is not only to resolve client's physical problem but also to concern his/her psychological adjustment. This case report is expected to provide a reference for care of similar clients.