This article describes a mature man with dyspnea due to Pulmonary alveolar proteinosis (PAP), that required urgent placement of an endotracheal tube and the extracorporeal membrane oxygenation (ECMO) to provide cardiopulmonary support for complete course of whole lung lavage. The period of nursing care was from April 17 to May 6, 2019. The author collected information by written interviews, interviews, medical record review, observation, physical assessment and use of Gordon's 11 health functional assessments. The patient's health problems were: impaired gas exchange, compromised ineffective family coping, and anxiety. During the nursing process, oxygenation function was closely monitored for successfully weaning the ECMO. Then, early intervention in rehabilitation therapy was used to improve the respiratory function. When facing the anxiety of patient, we provided disease-related information, accompanying to give psychological care, and flexible visiting to relieve anxiety. In addition, we held family meetings to help the patient's family to express their feelings, rebuilt family relationships and established adequate supports. This care experience can be shared as a reference in clinical practice.