Purpose: To investigate the role of human cerebral cortex in acupuncture analgesia by using magnetoencephalography (MEG) analysis. Materials and Methods: Twelve healthy subjects (mean age 22+2 years, male: female=1:1) were enrolled in this study. We randomized needled the acupuncture point L14 (Hegu) or control point at the thenar muscle with electrical stimulation with 1/3 Hz for 10 minutes. MEG recordings were obtained during the stimulation of electro-acupuncture simultaneously. Then the obtained data were analyzed by software of Neuromag. Activated dipoles were calculated and fitted to MRI imaging. The comparison between the magnitude of dipoles at different points were made by Student's t-test. Results: Electro-acupuncture at L14 resulted in activated dipoles at contralateral primary somatosensory area (SI) and bilateral secondary somatosensory area (SII) whereas electro-acupuncture at the control point only generated an activated dipole at SI. The magnitude of dipoles at SI during electro-acupuncture at L14 was significantly larger than that of the control point (p<0.01). Conclusion: The somatosensory elicited field by electro-acupuncture at L14 was significantly larger than that of the control point. SII is an important area for acupuncture analgesia. Evaluation of the effect of acupuncture analgesia by MEG recordings merits further investigation.
Purpose: To investigate the role of human cerebral cortex in acupuncture analgesia by using magnetoencephalography (MEG) analysis. Materials and Methods: Twelve healthy subjects (mean age 22+2 years, male: female=1:1) were enrolled in this study. We randomized needled the acupuncture point L14 (Hegu) or control point at the thenar muscle with electrical stimulation with 1/3 Hz for 10 minutes. MEG recordings were obtained during the stimulation of electro-acupuncture simultaneously. Then the obtained data were analyzed by software of Neuromag. Activated dipoles were calculated and fitted to MRI imaging. The comparison between the magnitude of dipoles at different points were made by Student's t-test. Results: Electro-acupuncture at L14 resulted in activated dipoles at contralateral primary somatosensory area (SI) and bilateral secondary somatosensory area (SII) whereas electro-acupuncture at the control point only generated an activated dipole at SI. The magnitude of dipoles at SI during electro-acupuncture at L14 was significantly larger than that of the control point (p<0.01). Conclusion: The somatosensory elicited field by electro-acupuncture at L14 was significantly larger than that of the control point. SII is an important area for acupuncture analgesia. Evaluation of the effect of acupuncture analgesia by MEG recordings merits further investigation.