This 59-year-old woman was diagnosed as breast cancer with bone metastasis. Shesuffered from radiating pain from her left hip to left foot for several months and developed progression within one week prior to this consultation. The physician prescribed oral analgesics and anti-inflammatory drugs as well as morphine injection, but her refractory left buttock and lower limb pain with poor response to all analgesic strategies was still noted. After one month of the acupuncture treatments, the score of visual analogue pain scale, the dosage of morphine and consumption of dexamethasone were all significantly decreased. In this case report, we demonstrated the acupuncture combine with analgesics can effectively alleviate pain.Acupuncture is beneficial to reduce pain and improve quality of life for cancer patients.