抗癌化學藥物治療原則簡介

Introduction to the Principles of Anticancer Chemotherapy Treatment

姜紹青(Shao-Chin Chiang)

《腫瘤護理雜誌》 6卷1期 (2006/06) Pp. 1-8

https://doi.org/10.6880/TJON.200606_6(1).01

摘要

本文的目的，在介紹抗癌化學治療的歷史、不同的臨床應用、應用的原則、與劑量強度的觀念。抗癌化學藥物治療效果已被許多大型臨床試驗證實，第一、抗癌化學治療是可治癒癌症的；第二、化學治療合併手術或放射線治療可提高早期癌病治療的療效。長期以來，癌症醫學界所努力的方向，就是如何藉由不同的方式來提高化療藥物的療效（減少無病復發率與提高總體存活率），同時減少嚴重的副作用。而現在正積極進行的各項研究，長期目標即是改善臨床治療效果，特別是長久以來對傳統化學治療有抗藥性的癌症。

關鍵字

抗癌化學治療 ； 輔助性化學治療 ； 緩和性化學治療 ； 劑量強度

並列摘要

The purpose of this article is to introduce the anticancer chemotherapy through the illustration of historical aspects, the different purposes and principles of application, and the concept of dose intensity. Anticancer chemotherapy has been demonstrated in many large-scale clinical trials. Firstly, it is possible to cure cancer by anticancer chemotherapy. Secondly, integrating chemotherapy into combined modality programs with surgery or radiation therapy in early stage of disease can increase clinical benefit. For many years, the oncologists have taken their effort in improving the efficacy of chemotherapy (reduce recurrence and elevate overall survival rate) and, at the same time, lowering the severe adverse effects with varieties of approaches. Currently, the long-term goal of the intense research effort is to improve the clinical outcome for cancer patient's undergoing treatment, especially focusing on cancers that traditionally have been resistant to conventional chemotherapy.

並列關鍵字

anticancer chemotherapy ； adjuvant chemotherapy ； palliative chemotherapy ； dose intensity