化學治療藥物所引起的神經病變

Neurotoxicity of Chemotherapeutic Agents

徐昌鴻(Chang-Hung Hsu)

《腫瘤護理雜誌》 9卷1期 (2009/06) Pp. 1-12

https://doi.org/10.6880/TJON.200906_9(1).01

摘要

神經毒性為病患接受化學治療中重要之課題，化學治療引起的神經病變是癌症病患常見的副作用，它可以影響各級的神經系統。通常化療有關之神經毒性常常和使用之劑量相關，且與癌症病患生活品質及化療結果的變化有關聯，不同腫瘤之症候群所產生的化療併發症也不同。神經病變會因病人存活和治療的時間加長而變常見，也會因化學治療劑量的累積而變得更嚴重，本篇報告主要指出各種化療相關之神經病變及其特徵，並討論相關之治療。

關鍵字

化學治療 ； 神經毒性 ； 周邊神經病變

並列摘要

Chemotherpeutic agents-related neurotoxicity is an important issue while patient undergoing chemotherapy. Neurological side effects are common to many chemotherapeutic agents, and they effect all levels of the nervous system. Usually neurotoxicity of these medications is dose-limiting, and neurotoxicity may compromise quality of life and change the result of chemotherapy. Differentiating the complications of chemotherapy from paraneoplatic syndrome is difficult. The incidence of neurotoxicity will increase as patients are surviving longer and being treated more aggressively with higher-dose regimens and combinations of treatment modalities. Recognizing these complications and addressing them will become a more frequent and challenging clinical problem for practicing neurologists.

並列關鍵字

chemotherapy ； neurotoxicity ； peripheral neuropathy