異體造血幹細胞移植後移植物抗宿主疾病所引起的皮膚病變及其護理

Care of Patient with Cutaneous Manifestation of Graft-versus-Host Disease after Allogeneic Hematopoietic Stem Cell Transplantation

蕭逸美(Ye-Mei Hsiao)

《腫瘤護理雜誌》 9卷2期 (2009/12) Pp. 23-31

https://doi.org/10.6880/TJON.200912_9(2).03

摘要

近年來造血幹細胞移植已有很大的進展，移植物抗宿主疾病仍然是移植後最常見的合併症。本篇報告主要指出移植物抗宿主疾病的致病機轉及危險因子。依據症狀出現的時間，移植物抗宿主皮膚疾病可以區分為急性疾病及慢性疾病。移植物抗宿主皮膚疾病的標準治療是加強免疫抑制同時併用局部支持療法。藉由文獻查證相關的不良反應顯示有必要發展以實證為基礎的照護準則，以促進護理人員對移植物抗宿主疾病患者的照顧。

關鍵字

異體造血幹細胞移植 ； 移植物抗宿主疾病 ； 護理照顧

並列摘要

Despite recent advancements in allogeneic hematopoietic stem cell transplantation, graftversus-host disease (GVHD) remains a major cause of morbidity and mortality following transplantation. This clinical review focuses on the pathogenesis and risk factor of GVHD. On the basis of the time of presentation, cutaneous GVHD has been originally divided into an acute and chronic disease. Standard treatment of cutaneous GVHD involves the intensification of immunosuppressive therapy with adequate topical supportive management. A review of the adverse events reported in the literature revealed the need to develop evidence-based nursing practices to promote the care of this complex patient population.

並列關鍵字

graft-versus-host disease ； allogeneic hematopoietic stem cell transplantation ； nursing care