The aims of withdrawing life-sustaining treatment (WLST) are eliminating the suffering and maintaining the best interest of patients with terminal illness while showing respect to the patient’s free will, safe-guarding dignity and delivering the highest quality of end-of-life care. Through combined hospice care, empathic communications and family meetings during palliative care, the patient and the family can gain insight into health condition and seek help. Ultimately, all details of end-of-life care can be well prepared and understood in the physical, psychological and spiritual aspects. This article discusses and shares the current concepts and protocols of WLST for terminally ill patients through literature reviews of recent researches and the WLST experiences in our hospital with hopes that nursing specialists can appreciate the purpose of WLST and subsequently improve their practical skills and knowledge of quality of end-of-life care.