自十六世紀開始,西方人前來越南貿易,教士團也隨之而來。據史料記載,黎莊宗帝元和元年(1533),有西方人名依泥樞(Ignetio)者自海上來,在南真縣(今南直縣)以及膠水縣所屬的幾個村莊傳教。從此,教士團繼續到中部如清化,中南部如沱灢傳教。可是至十六世紀末在大越的傳教事業還沒有可觀的進展,要到十七世紀至十八世紀末期,越南傳教事業才越來越發達。儘管十七世紀末十八世紀初北方和南方的政權陸續進行禁教政策,但教士團仍然的積極活動,所以傳教還是有收穫結果。在傳教過程中,越南政權和傳教士發生了衝突,甚至還導致屠殺。其原因在於:天主教對國人崇拜祖先的傳統信仰有點不重視,以及傳教士越來越直接干涉到越南內部的政治領域。
From the beginning of 15 century, European merchands have come to Vietnam for trading, while the christian missionaries also followed them. According to ancient materials, a missionary named IGNETIO in the First year of Nguyen Hoa during King Le Trang Tong'sreign (1533) came by sealine to the district of Nam Chan (now Nam Truc) and some villages of the Giao Thuy district. From that time, missionaries continued their works in the centre of Vietnam like Thanh Hoa province, in the Southem Centre like Da Nang City-But until the end of 16 century, the Christianism preaching did not progress much, it must be in the 17 and at the end of 18 centuries this work appeared to develop strongly.Despite the Christiamism prohibition policies done in turn by the Le and Trinh authority in the North and that of Nguyen sovereigns in the South, the missionaries' works still gained certain successes due to their active agitations.During the process of Christianism preaching, conflicts have appeared between missionaries with feudal authorities both in the North and in the South, this even led to missionary massacre. Its reason is that christianism did not respect the indigenous people's customs and habits as well as their belief of ancestors' worship. Otherwise the missionaries have done much deep interventions to political domain of Vietnam interior authority while pushing up the religieous propagation effects.