桂枝茯苓丸加黑木耳方對於肥胖性多發性卵巢囊腫症候群的臨床初步療效評估

Clinical Trial of Gui-Zhi-Fu-Ling-Wan and Auricularia Polytricha Formula in the Treatment of Obese Polycystic Ovary Syndrome Preliminary Clinical Therapeutics

陳彥霖(Yan-Lin Chen) ； 李耀泰(Yaw-Tay Li) ； 翁紹評(Shao-Ping Weng) ； 施景中(Ching-Chung Shih) ； 鄭鴻祥(Hung-Shiang Cheng) ； 陳啓楨(Chee-Jen Chen)

《臺灣中醫醫學雜誌》 5卷1期 (2006/06) Pp. 75-94

https://doi.org/10.30032/TJCM.200606.0007

摘要

Polycystic ovarian syndrome indiscriminately strikes women between the ages of puberty and menopause. It is the leading cause of female infertility, and if left untreated can lead to obesity, diabetes, heart disease, and endometrial cancer. Although metformin therapy have been some beneficial effects in PCOS patient, further investigation and controlled studies are necessary to evaluate long-term effect.
A number of reports show that Chinese herbs improve menstrual function, however, only few studies have been placebo-controlled. The aim of our study was to use a double blind, placebo-controlled, approach with assessment of menstrual function and BMI reduction. All of 72 Chinese women with obese polycystic ovary syndrome (PCOS) were randomized to receive Gui-zhi-fu-ling-wan and Auricularia polytricha Formula or placebo with l5g three times daily for 6 months. Anthropometric, endocrine, and ovarian ultrasound assessments were effected before and after 6 months treatment. Gui-zhi-fu-ling-wan and Auricularia polytricha Formula treatment, resulted in a significant decrease in Menstrual index, BMI, body weight, and Testosterone (p＜0.0001), as well as also decrease in triglycerides, and low-density lipoprotein (LDL). Gui-zhi-fu-ling-wan and Auricularia polytricha Formula is well tolerated by the majority of patients and may be clinically useful as an alternative treatment for metformin, particularly in patients having obese PCOS and menstrual disturbances.

關鍵字

桂枝茯苓丸加黑木耳方 ； 調經肥胖 ； 多發性卵巢囊腫 ； 雄性素過多 ； 高胰島素

並列摘要

Polycystic ovarian syndrome indiscriminately strikes women between the ages of puberty and menopause. It is the leading cause of female infertility, and if left untreated can lead to obesity, diabetes, heart disease, and endometrial cancer. Although metformin therapy have been some beneficial effects in PCOS patient, further investigation and controlled studies are necessary to evaluate long-term effect.
A number of reports show that Chinese herbs improve menstrual function, however, only few studies have been placebo-controlled. The aim of our study was to use a double blind, placebo-controlled, approach with assessment of menstrual function and BMI reduction. All of 72 Chinese women with obese polycystic ovary syndrome (PCOS) were randomized to receive Gui-zhi-fu-ling-wan and Auricularia polytricha Formula or placebo with l5g three times daily for 6 months. Anthropometric, endocrine, and ovarian ultrasound assessments were effected before and after 6 months treatment. Gui-zhi-fu-ling-wan and Auricularia polytricha Formula treatment, resulted in a significant decrease in Menstrual index, BMI, body weight, and Testosterone (p＜0.0001), as well as also decrease in triglycerides, and low-density lipoprotein (LDL). Gui-zhi-fu-ling-wan and Auricularia polytricha Formula is well tolerated by the majority of patients and may be clinically useful as an alternative treatment for metformin, particularly in patients having obese PCOS and menstrual disturbances.

並列關鍵字

Gui-zhi-fu-ling-wan and Auricularia polytricha Formula ； menstrual cycle obesity ； PCOS ； hyperandrogenism ； hyperinsulinemia