Optimization of Bone Scintigraphy Image Quality via the Taguchi-Methodology

利用田口方法在核醫骨骼攝影檢查影像品質最佳化評估

黃政凱(Cheng-Kai Huang) ； 蔡世傳(Shin-Chuan Tsai) ； 張賴昇平(Sheng-Pin Changlai) ； 林君宜(Chun-Yi Lin) ； 潘榕光(Lung-Kwang Pan) ； 鄭凱元(Kai-Yuan Cheng)

《中華放射線技術學雜誌》 30卷2期 (2006/12) Pp. 129-141

https://doi.org/10.30045/CJRT.200612.0008

摘要

本研究旨在評估臨床骨骼攝影參數之最佳化，研究之對象為45名腎功能正常之成年男性患者（患者以自願參加並簽完同意書）；在田口方法最佳化設計下，討論臨床上四個可能影響骨骼攝影影像品質因子（喝水量、注射劑量、等候時間、掃描速度）；影像品質之評估方式為ROI technique方法計算骨骼和軟組織相對比值，其數據將用田口方法L9(3^4)直交表做分析；實驗結果顯示對於成年男性而言，最佳化骨骼攝影影像品質參數為：患者飲水500毫升，等候時間為4小時，注射(上標 99m)Tc-MDP劑量為25mCi，掃描速度為16cm/min；此外，等候時間（信賴區間＞95%）和注射(上標 99m)Tc-MDP劑量（信賴區間＞95%）在骨骼攝影參數之中為主要決定影像品質之因子。本研究（骨骼攝影）使用田口方法可以得到在中每個因子獨立表現（重要性），藉由進一步分析（交互作用討論）可得到最佳化條件。

關鍵字

骨骼攝影 ； 骨骼對軟組織比 ； 影像品質

並列摘要

This study attempted to determine an optimal protocol and parameters for bone scintigraphy. Forty-five volunteer male patients without clinical evidence of renal disease were enrolled in this study. Four image-quality parameters were considered clinically patient hydration, time interval between injection and bone scanning, injection dose of 99mTc-MDP (methylene diphosphonate), and scan speed of the gamma camera. The bone-to-soft tissue ratio (B: ST) in bone scintigraphy was optimized utilizing the Taguchi method. Nine combinations of these four parameters were applied and the Taguchi method was followed exactly. Analytical results suggested that optimal protocol for bone scintigraphy in males was 500ml hydration, time interval of 4 hours, 25 mCi of (superscript 99m)Tc-MDP, and 16 cm/min scanning. Moreover, time interval (confidence interval＞95%) and injection dose (confidence interval＞95%) were the dominant parameters. Using the Taguchi method, the affect of each variable on overall bone scintigraphy performance was individually identified and, via further calculations, an optimum set of variables was obtained.

並列關鍵字

Bone scintigraphy ； bone-to-soft-tissue ratio ； image quality