乳癌患者之骨質密度評估

Association between Breast Cancer and Bone Mineral Density

何上芸(Shang-Yun Ho) ； 陳信宇(Hsin-Yu Chen) ； 郭瓊文(Chiung-Wen Kuo) ； 張東浩(Tung-Hao Chang) ； 李國維(Kwo-Whei Lee) ； 廖瓊櫻(Chiung-Ying Laio) ； 李明哲(Ming-Che Lee) ； 田雨生(Yeu-Sheng Tyan)

《中華放射線技術學雜誌》 30卷2期 (2006/12) Pp. 87-94

https://doi.org/10.30045/CJRT.200612.0002

摘要

The purpose of the study was to assess the effect of bone mineral density (BMD, g/cm^2) in post-treatment women with breast cancer. A total of 50 women without metastasis (aged 39-68 years, mean age of 51.1±6.7 years) underwent BMD measurement at the lumbar spine and femoral neck by using dual energy X-ray absorptiometry (DXA). Anthropometric data and reproductive history were collected by direct interview using a structured questionnaire. According to the definition of osteoporosis, the mean bone mineral density at all sites demonstrated normal. After analysis of risk factors, no significant differences between physical activity and BMD at measured sites were found among subjects (p＞0.05). In menstrual situation (pre-menopause, below 5 years menopause, over 5 years menopause), the group of over 5 years menopause was lower than the pre-menopausal group for T-Score at lumbar spine (p=0.034). In linear regression scatter, significant correlation were found between the age at menarche and BMD for lumbar spine (r=-0.41, p=0.005), left femoral neck (r=-0.30, p=0.045) and right femoral neck (r=-0.3, p=0.05). The age at the first pregnancy and BMI was positively associated with lumbar BMD, left femoral neck BMD, respectively (r=0.31, p=0.03; r=0.33, P=0.02) The factor of younger age at menarche, older age at the first pregnancy and obesity elevated BMD. These results suggest that BMD would not decrease at post-treatment women with breast cancer.

關鍵字

乳癌 ； 骨質密度 ； 雙能量X光骨質密度儀 ； 骨質疏鬆症

並列摘要

The purpose of the study was to assess the effect of bone mineral density (BMD, g/cm^2) in post-treatment women with breast cancer. A total of 50 women without metastasis (aged 39-68 years, mean age of 51.1±6.7 years) underwent BMD measurement at the lumbar spine and femoral neck by using dual energy X-ray absorptiometry (DXA). Anthropometric data and reproductive history were collected by direct interview using a structured questionnaire. According to the definition of osteoporosis, the mean bone mineral density at all sites demonstrated normal. After analysis of risk factors, no significant differences between physical activity and BMD at measured sites were found among subjects (p＞0.05). In menstrual situation (pre-menopause, below 5 years menopause, over 5 years menopause), the group of over 5 years menopause was lower than the pre-menopausal group for T-Score at lumbar spine (p=0.034). In linear regression scatter, significant correlation were found between the age at menarche and BMD for lumbar spine (r=-0.41, p=0.005), left femoral neck (r=-0.30, p=0.045) and right femoral neck (r=-0.3, p=0.05). The age at the first pregnancy and BMI was positively associated with lumbar BMD, left femoral neck BMD, respectively (r=0.31, p=0.03; r=0.33, P=0.02) The factor of younger age at menarche, older age at the first pregnancy and obesity elevated BMD. These results suggest that BMD would not decrease at post-treatment women with breast cancer.

並列關鍵字

breast cancer ； bone mineral density ； dual energy x-ray absorptiometry ； osteoporosis