磁振頻譜定量脂肪比例：SAGE及LC model分析結果比較

MRS Quantification of Fat Ratio: Comparison between SAGE and LC Model Analysis

孫進智(Chin-Chih Sun) ； 李振昌(Chen-Chang Lee) ； 陳清輝(Chin-Hui Chen) ； 簡文彬(Wen-Pin Chien) ； 趙世裕(Shih-Yu Chao)

《中華放射線技術學雜誌》 35卷4期 (2011/12) Pp. 215-220

https://doi.org/10.30045/CJRT.201112.0003

摘要

非酒精性脂肪肝病變可能導致肝硬化及肝癌。本研究以GE Signa 3T評估脂肪樣品定量之準確度，分別將磁振頻譜訊號在SAGE及LC Model軟體進行數據分析，歸納出SAGE高度分析比例為5.07±0.61％、積分分析之比例為0.47±0.21％。基線校正後高度分析比例為4.42±0.65％、積分分析之比例為0.35±0.19％。LC Model分析之數值為4.0-4.7％之間。實驗發現SAGE頻譜高度亦能反應出脂肪相對含量，因實際運用時，頻譜高度較積分更容易客觀取得，在被測物移動或T2*等干擾頻譜積分狀況下，頻譜亦能提供相對定量之參考。在5%之脂肪比例之相對定量上，本研究發現SAGE及LC Model皆能提供定量上之參考，未來可應用於脂肪肝之診斷及治療追蹤上。

關鍵字

脂肪比例 ； 磁振頻譜 ； SAGE ； LC Model ； 定量分析

並列摘要

Nonalcoholic fatty liver disease (NAFLD) can generally induce cirrhosis and hepatocellular carcinoma. In this study, GE Signa 3T quantitative assessment the accuracy of fat samples with fast scan method. MR Spectroscopy relaxation signal was post-processed with SAGE and LC Model. SAGE quantities fat ratio with peak height analysis was 5.07±0.61 %. Integral analysis was 0.47±0.21 %. Peak height analysis with base line correction was 4.42±0.65 %. Integral analysis with base line correction was 0.35±0.19 %. LC model analysis was between 4.0-4.7%. The study shows peak height analysis with SAGE can indicate correct relative quantity. In clinical application, peak height is easier to obtain the correct objective value compare to integral analysis especially with motion and T2* relaxation, which will interfere the spectral area quantity analysis. The study shows fast scan MR spectroscopy parameter can offer a relative quantity of 5% fat ratio, by using SAGE peak height analysis and LC Model software, which may be used for follow up diagnosis of fatty liver disease.

並列關鍵字

Fat ratio ； MR spectroscopy ； SAGE ； LC Model ； Quantity analysis