The case of the article is the diagnosis in patients with acute ischemic stroke (AIS) causing ischemic stroke secondary subsequently due to aortic dissection (AD). The diagnosis in AIS adopts specific computed tomography scan protocol to provide a series of imaging.AD leading to AIS is considered as a rare cause. It can be fatal if intravenous recombinant tissue plasminogen activator (rt-PA) or interventional therapy is not given immediately. In order to avoid severe outcome and sequels, computed tomography needs to be done to exclude the possibility of AD.