Evaluation of Prognostic Factors of Stage III N1 Colorectal Cancer: Analysis of Risk Factors of Colorectal Cancer

Stage III N1大腸直腸癌預後因子之評估：大腸直腸癌危險因子分析

蔣昇甫(Sum-Fu Chiang) ； 陳進勛(Jinn-Shiun Chen) ； 張簡俊榮(Chung Rong Changchien) ； 唐瑞平(Rei-Ping Tang) ； 游耀東(Yau-Tong You)

《中華民國大腸直腸外科醫學會雜誌》 17卷4期 (2006/12) Pp. 95-101

https://doi.org/10.6312/SCRSTW.2006.17(4).09515

並列摘要

Purpose: To investigate the prognostic factors associated with a better outcome in patients with stage III N1 colorectal cancer.Methods: We analyzed data from the Registry of Colorectal Cancer, Colorectal Section, Chang Gung Memorial Hospital. There were 652 patients with stage III N1 disease, who were diagnosed from January 1995 to March 2000. All patients were followed for at least 5 years. We used lineal regression for each factor, and cox regression for their independence. The p value smaller than 0.05 was used for significance in this study.Results: In colon cancer patients, anemia, CEA level, T stage, and lymph node metastatic rate correlated with survival and liver metastasis (p ＜ 0.05). In rectal cancer patients, anemia, CEA level, T stage, smoking, alcohol consumption, and adjuvant therapy correlated with survival and local recurrence (p ＜ 0.05). However, lymph node metastatic rate was not so powerful. Smoking status and alcohol consumption didn't show significance in multivariate analysis.Conclusions: The results suggest that factors other than TNM staging, such as anemia, T stage, and CEA level could be used to further stratify stage III N1 colorectal cancer patients. Such stratification may assist in the choice of adjuvant therapy and influence follow-up frequency.

並列關鍵字

Colorectal cancer ； Prognosis ； Risk factors ； CEA ； Anemia