Weekly Regimen of Low-Dose 5-Fluorouracil and Leucovorin as Adjuvant Chemotherapy for Colorectal Cancer

目的　我們在此報告本院第三期大腸直腸癌的患者在手術後，接受輔助化學治療或化學放射治療所使用的處方及其成效。方法　自西元1998年3月至2006年3月，共有120位常規手術患者，手術後接受每週一次門診注射化學針劑，使用藥物為5-FU 500 mg/平方公尺及葉酸100 mg。其中39位病人同步接受五週半、總劑量5040 cGy 的放射治療。共89位病人完成治療者納入存活率之計算。結果　三年存活率及三年無疾病存活率是75.19%、59.63%。五年存活率及五年無疾病存活率分別是 59.63%、48.5%。三級以上的毒性反應主要是放射性直腸炎15.38% 及一位病人有發燒性嗜中性白血球低下症。二級以下的毒性反應主要是疲累感18.33%、噁心厭食4.17%、腹瀉19.17%、口腔破皮或胃發炎5.0%。因為毒性反應造成治療中斷佔9.1%，其中包含一位因人工靜脈血管造成右上臂和右頸靜脈深部靜脈栓塞。結論　對於大部分的患者而言，既使在合併放射治療下，此方法仍是有效且毒性是可以忍受的。

關鍵字

大腸直腸癌；化學放射治療；輔助化學治療

並列摘要

Background. The aim of this study is to present the experiences in our institution on adjuvant chemotherapy or chemoradiation for patients suffering stage Ⅲ colorectal cancer. Methods. One hundred twenty patients between March 1998 and March 2006 who underwent one-stage surgery were subsequently put under a weekly regimen of 5-FU at 500 mg/m2 with LV at flat 100mg for 24 times. Among them, thirty nine patients received concurrent long-course radiation with total dosage of 5040cGy. Eighty-nine patients that completed chemotherapy or chemoradiation were enrolled in the survival analysis. Results. Three-year OS and DFS rates were 75.19% and 59.63%. Fiveyear OS and DFS rates were 59.63% and 48.5%, respectively. Total toxicity rate on grade 3 and 4 was mainly due to radiation proctitis in 15.38% patients. One (0.83%) patient suffered febrile neutropenia. The grade 1 or 2 toxicity were mainly from fatigue in 18.33% patients, nausea/anorexia in 4.17%, diarrhea in 19.17% patients as well as stomatitis/mucositis in 5.0% patients. Clinical physicians' practice was responsible toxicity for 9.1% of patients, including one Port-A-related right arm deep vein thrombosis.

並列關鍵字

Colorectal cancer ； Chemoradiation ； Adjuvant chemotherapy

國際替代計量

Weekly Regimen of Low-Dose 5-Fluorouracil and Leucovorin as Adjuvant Chemotherapy for Colorectal Cancer

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