Schwannomas of the colon are extremely rare, and it is necessary to treat them by radial excision with a wide margin because of their tendency to recur locally and become malignant if inadequately treated. In the present study, we report a rare case of a colonic schwannoma that was successfully treated by surgical resection in our department. Immunohistochemistry revealed that the tumor was positive for S-100 and negative for C-KIT, smooth muscle actin, CD21, CD34, and CD35. The patient was therefore diagnosed with a schwannoma, not a gastrointestinal stromal tumor( GIST). We report the findings of endoscopy, radiology, and pathology in a patient with colonic schwannoma. The literature on colonic schwannomas has been reviewed.