Comparisons of Characteristics and Outcome of Colorectal Cancer in Different Age Categories: A Retrospective Analysis of a Single Institution in Taiwan

在不同年齡組比較大腸直腸癌的臨床特點和預後結果：在台灣單一機構的回顧性分析

傅軍毓(Chun-Yu Fu) ； 饒樹文(Shu-Wen Jao) ； 吳昌杰(Chang-Chieh Wu) ； 李家政(Chia-Cheng Lee) ； 李才宇(Tsai-Yu Lee) ； 陸懷恩(Huai-En Lu) ； 蕭正文(Cheng-Wen Hsiao)

《中華民國大腸直腸外科醫學會雜誌》 22卷3期 (2011/09) Pp. 57-64

https://doi.org/10.6312/SCRSTW.2011.22(3).10004

摘要

Purpose. The purpose of this retrospective study was to investigate differences in clinic features, pathologic findings, and outcomes of patients with colorectal cancer among different age groups.Methods. Colorectal cancer patients (N = 1116) who had undergone surgical treatment were divided into three groups according their age: young (40 years and under), middle-age (41-70 years) and old (71 years and above). The medical records of all patients were reviewed, and compared by age categories.Results. Tumor location, N status, M status, and TNM stage were associated with age categories, but grade, histological subtype, and T stage were not. There were 32 patients (3.2%) with diagnosis of colorectal cancer found in screening programs, and they were all in group M (p ＜ 0.001). Hematochezia (54.3%) was the most common symptom leading to diagnosis. Abdominal pain was more prevalent in the young group (30.4 vs. 20.9 vs. 15.4%, p = 0.03), and obstruction was more frequent in old group (6.5 vs. 8.4 vs. 19.2%, p ＜ 0.01). The average 5-year overall survival rates of the young and middle-age groups were similar and significantly better than that of the old group (p ＜ 0.001) when compared overall, or by stage.Conclusion. Young patients were diagnosed at a later stage, but did not have a worse overall outcome. Although the suspicion of malignancy in the young is low, symptoms such as abdominal pain or change in bowel habit should not be regarded lightly. If the disease is detected early, survival of young patients may be improved even better.

關鍵字

年輕 ； 大腸癌 ； 腺癌 ； 年齡

並列摘要

Purpose. The purpose of this retrospective study was to investigate differences in clinic features, pathologic findings, and outcomes of patients with colorectal cancer among different age groups.Methods. Colorectal cancer patients (N = 1116) who had undergone surgical treatment were divided into three groups according their age: young (40 years and under), middle-age (41-70 years) and old (71 years and above). The medical records of all patients were reviewed, and compared by age categories.Results. Tumor location, N status, M status, and TNM stage were associated with age categories, but grade, histological subtype, and T stage were not. There were 32 patients (3.2%) with diagnosis of colorectal cancer found in screening programs, and they were all in group M (p ＜ 0.001). Hematochezia (54.3%) was the most common symptom leading to diagnosis. Abdominal pain was more prevalent in the young group (30.4 vs. 20.9 vs. 15.4%, p = 0.03), and obstruction was more frequent in old group (6.5 vs. 8.4 vs. 19.2%, p ＜ 0.01). The average 5-year overall survival rates of the young and middle-age groups were similar and significantly better than that of the old group (p ＜ 0.001) when compared overall, or by stage.Conclusion. Young patients were diagnosed at a later stage, but did not have a worse overall outcome. Although the suspicion of malignancy in the young is low, symptoms such as abdominal pain or change in bowel habit should not be regarded lightly. If the disease is detected early, survival of young patients may be improved even better.

並列關鍵字

Young ； Colorectal cancer ； Adenocarcinoma ； Age