Purpose. Primary adenocarcinoma of the appendix is a rare condition. Institutions around the world have tried to find out the best treatment protocol for these patients. We perform a retrospective chart review, at our hospital, to analyze our treatment result of the past 15 years and compare them to those published in the literature.Methods. A total of 16 patients are analyzed. Patient demographics, presentation, peri-operative data and total survival are compared.Results. There is a trend of survival benefit for patients who receive operation with curative intent. A trend of survival benefit can be seen in patients who receive hyperthermia therapy for pseudomyxoma peritonei.Conclusion. The current practice in our hospital for primary adenocarcinoma of the appendix is comparable to that published in the literature. There is a room for the practice of cytoreductive surgery with hyperthermic intraoperative intraperitoneal chemotherapy for appendiceal pseudomyxoma peritonei. Referral centers should be established in Taiwan to provide best treatment options for these patients.