Goblet Cell Carcinoid of the Appendix: Diagnosis, Management and Literature Review

闌尾部位的杯狀細胞類癌，診斷，處置與文獻回顧

曾文科(Wen-Ko Tseng) ； 范仲維(Chung-Wei Fang) ； 李麗玉(Li-Yu Lee)

《中華民國大腸直腸外科醫學會雜誌》 25卷2期 (2014/06) Pp. 55-62

https://doi.org/10.6312/SCRSTW.2014.25(2).10303

摘要

目的　闌尾部位的杯狀細胞類癌是一種非常少見的腫瘤，本篇目的在報告於本院處理此一腫瘤的經驗與分析最近文獻上的進展。方法　利用病例回顧與病理組織回顧等方式，我們回溯從1983到2007年總共24年間所有的闌尾檢體或是右側大腸檢體含闌尾部分，所有檢索出來的檢體均由同一位病理科醫師進行再次檢驗。結果　總共有43803件闌尾部檢體，其中有39件診斷為類癌，這39件中僅有10件最終診斷為杯狀細胞類癌。男女比例剛好為一比一。所有病人都沒有手術後死亡案例，有兩位婦女有腹腔內轉移，但接受積極治療後至少有20個月的存活。結論　闌尾部杯狀細胞類癌的臨床表現是介於類癌與腺癌之間，然而積極的治療的確可以給病人更佳的存活機率。

關鍵字

杯狀細胞類癌 ； 腺類癌 ； 闌尾部 ； 闌尾切除 ； 右側大腸切除

並列摘要

Objective. Goblet cell carcinoid is a very rare neoplasm of the gastrointestinal tract. In the present study, we share the treatment experience related to goblet cell carcinoid of the appendix in our hospital and review recent advances reported in the literature. Methods. In a chart and pathological review of cases treated at our hospital from 1983 to 2007, we selected cases with available appendectomy specimens or right hemicolectomy specimens with appendices. All appendectomy specimen slides were validated by final diagnosis and reviewed by a single pathologist. Results. A total of 43,808 specimens were reviewed in this present study, of which. 39 cases were diagnosed as carcinoid tumor. Of these 39 cases, only 10 had a final diagnosis of goblet cell carcinoid of the appendix. The male-to-female ratio was 1:1. There was no reported peri-operative mortality. Two female patients had peritoneal dissemination and survived with stable disease after 20 months of follow-up. Conclusions. The clinical behavior of goblet cell carcinoid was between the classical carcinoid and adenocarcinoma of the appendix. More aggressive treatment improved patient outcome.

並列關鍵字

Goblet cell carcinoid ； Adenocarcinoid ； Appendectomy ； Right hemicolectomy