- 期刊
A Retrospective Study of Elderly Colorectal Cancer Patients-The Longitudinal Result
老年人大腸直腸癌病人回顧性縱向分析
摘要
目的 本研究的目的是探討在國泰綜合醫院八十歲以上的結腸直腸癌患者的縱向分析結果。材料與方法 本研究採用回顧性縱向研究設計。從國泰綜合醫院結腸直腸癌註冊資料庫和病歷得到結腸直腸癌癌症分期診斷，治療數據和結果。我們分析八十歲以上的結腸直腸癌患者總體生存率。結果 自2000年1月至2010年12月共有234位八十歲以上的結腸直腸癌患者在國泰綜合醫院接受治療。176位八十歲以上患者被診斷為結腸癌和58位確診為直腸癌。5年總生存率為如下：結腸癌：I期：67.1%，II期39.6%，III期17.4%，IV期：9.8%；直腸癌：I期：40.9%，II期：24.1%，III期57.1%，IV期：0%。結論 在我們的系列中，八十歲以上老人結腸直腸癌患者的總生存率比年輕患者有顯著更差的存活率。這種現象可能是因為年齡相關的器官功能衰退和其他合併症。老年患者對於手術治療和承受化療副作用的耐受性較低。對於老年患者，我們有更多治療上的挑戰。
並列摘要
Purpose. To examine the longitudinal result of colorectal cancer (CRC) in elderly patients aging over 80 at the Cathay General Hospital (CGH). Materials and Methods. This study used a retrospective longitudinal research approach. Information of cancer stage at initial diagnosis, treatment data, and outcomes were obtained from CGH medical records and the registry database of colorectal cancer. The overall survival rate was analyzed in this study as well. Results. There were 234 elderly CRC patients aging over 80 receiving treatment at the CGH from January of 2000 to December of 2010. 176 octogenarians and nonagenarians were diagnosed with colon cancer, and 58 other elderly patients were diagnosed with rectal cancer. The 5-year overall survival rate was as follows: colon cancer: stage I: 67.1%, stage II: 39.6%, stage III: 17.4%, stage IV: 9.8%; rectal cancer: stage I: 40.9%, stage II: 24.1%, stage III: 57.1%, stage IV: 0%. Conclusion. In this study, elderly CRC patients have significantly worse overall survival rate than younger CRC patients. The phenomenon may result from age-related declines in organ functions and medical comorbidities. It is possible that elderly patients have less tolerance to the surgical treatment and toxicity of chemotherapy. There are more challenges in treating elderly patients. Therefore, further studies are required for treating elderly patients with CRC.