Colonic perforations may occur after colonoscopy and are commonly associated with peritonitis and intraperitoneal free air. Besides pneumoperitoneum, subcutaneous emphysema, pneumomediastinum, and pneumoretroperitoneum may be rare signs of retroperitoneal colonic perforations. This report presents the case of an 80-year-old woman who developed subcutaneous emphysema, pneumothorax, pneumomediastinum, pneumoretroperitoneum, and pneumoperitoneum after a colonoscopic examination. The patient underwent an emergency laparoscopic repair of a retroperitoneal colonic perforation in the sigmoid colon diverticulum. Consequently, she had uneventful postoperative recovery and was discharged nine days postoperatively. Pros and cons of possible treatment options for colonic perforation during colonoscopy, such as primary suture by surgeons, endoscopic clipping or conservative treatment, were also addressed in this report.