This case report discusses the terminal situation of a hemodialysis patient who is ineligible for renal transplantation. It uses Watson's theory of human science and human care to help the patient develop and maintain a sense of hope. The duration of nursing care for this patient was from September 4, 2003 to October 2, 2003. After our evaluation, we found that the patient suffered from: 1. a feeling of hopelessness, 2. hypervolemia, 3. ineffective protecting ability, and 4. constipation. Guided by Watson's theory, we provided ten items of human care to assist this patient accept the fact that he could not receive a renal transplant. We hope that the patient will regain hope, face long-term hemodialysis with a healthy attitude, and further increase his quality of life.