As the rate of peritoneal dialysis peritonitis decline over the years, non-infective complications of peritoneal dialysis gradually increase. Non-infective complications of peritoneal dialysis can be classified into mechanical and metabolic. Increased in non-infective complications of peritoneal dialysis are due to indwelling peritoneal catheter, increased intraperitoneal pressure and dextrose containing dialysate and its metabolites. Clinically, we need to focus on preventive strategies in order to prolong the lifespan of peritoneal dialysis catheter and lower the complications of noninfectious complications. The strategies should cover clinical knowledge of the peritoneal dialysis caring team, assessment in catheter implantation, surgeons’ skill in implantation and providing psychosocial support for the patients, and the use of biocompatible dialysate in order to prolong peritoneal dialysis treatment years and to improve quality of life for the patients.