萬古黴素抗藥性腸球菌感染或移生個案之腸道移生情形分析

Vancomycin-resistant Enterococci (VRE) Intestinal Colonization Surveillance in 37 VRE-infected Patients: A Retrospective Analysis

賴重彰(Chorng-Jang Lay) ； 王俊隆(Chun-Lung Wang) ； 陳雅嵐(Ya-Lan Chen) ； 陳香伶(Hsiang-Ling Chen) ； 賴鵬如(Peng-Lu Lai) ； 沈美蘭(Mei-Lan Shen) ； 蔡鎮吉(Chen-Chi Tsai)

《感染控制雜誌》 19卷1期 (2009/02) Pp. 1-9

https://doi.org/10.6526/ICJ.200902_19(1).0001

摘要

The rapid increase of infections caused by vancomycin-resistant enterococci (VRE) has resulted in the increase in morbidity, mortality and medical costs in recent years. We retrospectively analyzed intestinal colonization of VRE in patients infected by these pathogens in our hospita1. Between January 1 and December 31, 2007, a total of 37 patients (with 38 episodes and 50 isolates) were collected and surveyed. Urine (46%) was the most frequent1y encountered specimen. Among the 38 episodes, the criteria for discontinuation of isolation care, which were three consecutive negative results for stool surveillance, could be met in only three episodes. For those being kept for isolation care, the major reason was due to the persistence of positive stool findings (63%). Persistent stool carriage of VRE was associated with the use of glycopeptides antibiotics within one month of the infections (91% vs. 22%, p＜0.05). In order to control the increase of VRE infections and to reduce medical expenses, judicious use of glycopeptide should be encouraged and a more stringent isolation policy should be implemented.

關鍵字

萬古黴素 ； 腸球菌 ； 腸道移生

並列摘要

The rapid increase of infections caused by vancomycin-resistant enterococci (VRE) has resulted in the increase in morbidity, mortality and medical costs in recent years. We retrospectively analyzed intestinal colonization of VRE in patients infected by these pathogens in our hospita1. Between January 1 and December 31, 2007, a total of 37 patients (with 38 episodes and 50 isolates) were collected and surveyed. Urine (46%) was the most frequent1y encountered specimen. Among the 38 episodes, the criteria for discontinuation of isolation care, which were three consecutive negative results for stool surveillance, could be met in only three episodes. For those being kept for isolation care, the major reason was due to the persistence of positive stool findings (63%). Persistent stool carriage of VRE was associated with the use of glycopeptides antibiotics within one month of the infections (91% vs. 22%, p＜0.05). In order to control the increase of VRE infections and to reduce medical expenses, judicious use of glycopeptide should be encouraged and a more stringent isolation policy should be implemented.

並列關鍵字

Vancomycin ； enterococcin ； intestinal colonization