檀香精油對人類角質層蛋白質羰基化的影響

Effect of Sandalwood Oil on Human's Stratum Corneum Protein Carbonylation by an In Vivo Detecting Method.

蔡豐仁(Feng-Jen Tsai) ； 張簡美新(Mei-Hsing Chang Chien) ； 鄭智交(Zhi-Jiao Cheng) ； 陳正吉(Cheng-Chi Chen)

《美容科技學刊》 9卷1期 (2012/03) Pp. 5-12

https://doi.org/10.30001/JIES.201203.0001

摘要

檀香（Sandalwood）為檀香科植物檀香（Santalum album L），已普遍使用於食品及化妝品中。而檀香精油主要活性成份為α－檀香萜醇和β－檀香萜醇（α－β－Santalol），其次為檀萜烯（Santene）、α－檀香烯和β－檀香烯（α－，β－Santalene）、檀萜烯酮（Santenone）、檀萜烯酮醇（Santenone alcohol）、及少量的檀香萜酸（Santalic acid）、檀油酸（Teresantalicacid）、紫檀萜醛（Santal aldehyde）等。有研究指出檀香具有抗氧化的活性，另外也顯示有抗皮膚腫瘤的效果，並顯示有很低的經口（oral）及經皮（dermal）急性毒性。本研究將利用偵測皮膚角質蛋白質羰基暴露的方法，以評估檀香精油對人類角質層蛋白質羰基化的影響，以做為研製化妝品的重要參考。結果顯示含0.5%檀香精油之試驗配方對於角質層蛋白質的羰基化有顯著的增加，其對角質層蛋白質可能會產生光誘導性的氧化傷害。

關鍵字

抗氧化 ； 檀香 ； 羰基

並列摘要

Sandalwood (Santalum album L) is a fragrant wood from which oil is derived for use in food and cosmetics. It has low acute oral and dermal toxicity in laboratory animals. The various constituents have been identified in sandalwood oil. The -and -santalol are the major constituent. The other components have santene, α-and β-santalene, santenone, santenone alcohol, santalic acid, teresantalic acid and santal aldehyde. It have been reported that sandalwood extracts with antioxidant activity and sandalwood oil prevent skin tumour development.We have developed a viable protocol for in vivo evaluation of antioxidative properties of a compound based on detecting the extent of protein oxidation. The antioxidative properties of sandalwood oil will be evaluated by the in-vivo developed method detecting the extent of protein oxidation in human stratum corneum by immunoanalysis and a non-evasive method for collecting scalp protein by cloth patch. Our results indicated that 0.5% sandalwood oil may enhance the level of exposed carbonyl group in human stratum corneum protein by sunlight exposure.

並列關鍵字

Antioxidation ； Sandalwood ； Carbonylation

參考文獻

An, S.,Lee, A. Y.,Lee, C. H.,Kim, D. W.,Hahm, J. H.,Kim, K. J.,Moon, K. C.,Won, Y. H.,Ro, Y. S.,Eun, H. C.(2005).Fragrance contact dermatitis in Korea: a joint study.Contact Dermatitis.53(6),320-3.

Berlett, B. S.,Stadtman, E. R.(1997).Protein oxidation in aging, disease, and oxidative stress.J Biol Chem.272(33),20313-6.

Bommareddy, A.,Hora, J.,Cornish, B.,Dwivedi, C.(2007).Chemoprevention by alpha-santalol on UVB radiation-induced skin tumor development in mice.Anticancer Res..27(4B),2185-8.

Burdock, G. A.,Carabin, I. G.(2008).Safety assessment of sandalwood oil (Santalum album L.).Food Chem Toxicol.46(2),421-32.

Dwivedi, C.,Zhang, Y.(1999).Sandalwood oil prevent skin tumour development in CD1 mice.Eur J Cancer Prev..8(5),449-55.