After completion of human genome project (HGP) in 2003, biology went into ”post-genome era.” Many Asian countries have markedly different approaches to craving out a niche in the Asian biotech arena. This study analyzes the total factor productivity (TFP) of Asian biotech firms using the stochastic production frontier approach. The stochastic production frontier approach allows us to separate the random error from the inefficiency and decompose TFP productivity change into a technical change component, a return to scale component, and a component associated with change in technical efficiency. The empirical results show that the TFP upgrading mainly results from efficiency improvement and scale component, and the contribution of technical change is negative. Furthermore, the technology change is non-neutral with respect to inputs, and tends to use less labor and more capital.