Incidence of pediatric brain tumor is the third place in childhood cancer. Hospitalization of school-age children with brain tumors is obviously a necessary process and the patients are always suffering difficult times due to the strange, restless, anxious and their fear to the hospital environments and situations. Children become more difficult to adapt to illness and hospitalization caused by stress and psychological trauma, unless they can cope the behaviors well, or the hospitalization will cause long-term impact of children. Therefore, nurses use to help children effectively coping behaviors, and provide more support and reduce the stress source which the child must face, and adjustment together through entire in hospital period process. The present paper aims to explore the stress-induced behavioral expression in school-age children with brain tumor during hospitalization based on 3 cases study, to discuss the care management of these children.