阿茲海默氏病病患之記憶障礙檢測

Memory Impairment in Alzheimer's Disease

徐榮隆(Jung Lung Hsu) ； 邱浩彰(Hou Chang Chiu)

《輔仁醫學期刊》 4卷3期 (2006/09) Pp. 113-119

摘要

Alzheimer's disease (AD) is one of the most common neurological diseases in aged people, with a prevalence of about 2.5%. With AD, memory impairment is the most common symptom. In this study, we collected 213 different stages of AD and used the Chinese version of the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) neuropsychological battery to evaluate the dementia patients. We selected the memory subtest, which includes word list memory, word list recall, and word list recognition, and the verbal subtest in this battery and determined relationships between the memory subtest and other factors. Our results showed the global cognition and memory function gradually deteriorated as the dementia stage increased. The most significant correlation with memory ratio was word list recognition (p＜0.001), which represents temporal lobe function. The Memory ratio did not show a strong correlation with frontal lobe function (p=0.24). This finding is compatible with previous studies and also demonstrates that the Chinese version of the CERAD neuropsychological battery can be applied to the field of study of cognitive dementia.

關鍵字

阿茲海默氏病 ； 記憶障礙 ； 阿茲海默氏病聯合登錄研究組織

並列摘要

Alzheimer's disease (AD) is one of the most common neurological diseases in aged people, with a prevalence of about 2.5%. With AD, memory impairment is the most common symptom. In this study, we collected 213 different stages of AD and used the Chinese version of the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) neuropsychological battery to evaluate the dementia patients. We selected the memory subtest, which includes word list memory, word list recall, and word list recognition, and the verbal subtest in this battery and determined relationships between the memory subtest and other factors. Our results showed the global cognition and memory function gradually deteriorated as the dementia stage increased. The most significant correlation with memory ratio was word list recognition (p＜0.001), which represents temporal lobe function. The Memory ratio did not show a strong correlation with frontal lobe function (p=0.24). This finding is compatible with previous studies and also demonstrates that the Chinese version of the CERAD neuropsychological battery can be applied to the field of study of cognitive dementia.

並列關鍵字

Alzheimer's disease ； memory impairment ； CERAD