宜蘭鄉村地區中老年人血脂肪異常盛行率與控制概況

Prevalence and Management of Dyslipidemia among Middle-aged and Elderly in I-Lan Communities of Northeastern Taiwan

李威儒(Wei-Ju Lee) ； 陳亮恭(Liang-Kung Chen) ； 陳振文(Tzen-Wen Chen) ； 黃信彰(Shinn-JangHwang) ； 邱淑媞(Shu-Ti Chiou)

《北市醫學雜誌》 1卷4期 (2004/10) Pp. 459-467

https://doi.org/10.6200/TCMJ.2004.1.4.11

摘要

Background: Dyslipidemia is a major risk factor for cardiovascular diseases, and it is particularly true in the middle-aged and elderly. Prevalence of dyslipidemia in Taiwan was mostly described by hospital-based evaluations, community-based investigations regarding to dyslipidemia were relatively lacking. The purpose of this study isto explore the prevalence of dyslipidemia among residents in I-Lan county, and the quality of dyslipidemia management is also evaluated. Material and Methods: People aged over 40 residing in 3 townships of I-Lan county were randomly enrolled into study. Each subject has received serial physical examinations, history taking, anthropometric measurements and laboratory survey by well-trained research staff. Blood biochemistry tests including serum total cholesterol (TCHO), triglycerides (TG) and high-density lipoprotein cholesterol (HDL-C) were measured. Serum low-density lipoprotein cholesterol (LDL-C) were calculate according to Friedewald Formulator. Quality of dyslipidemia management was evaluated on the basis of Adult Treatment Panel Il(ATP II) and related regulations of National Health Insurance Bureau, Taiwan. Results: In total, 1069 subjects were enrolled with the mean age of 64.4±11.3 years and female predominance (55.6% vs. 44.4%). The mean TCHO and TG of the whole subjects were 208.5±40.6 mg/dl, and 130.7±87.7 mg/dI, respectively. Among them, 920 subjects have their HDL-C levels tested. The mean DHL-C and LDLC levels were 46.3±15.6 mg/dI and 135.7±37.3 mg/ dl, respectively. In our study, females had significantly higher TCHO (214.5±42.0 mg/dI vs. 200.8±37.4 mg/ dl, p＜O.OO1), higher HDL-C (48.3±17.3 mg/dl vs. 43.8±17.5 mg/dI, p＜O.OO1), and higher body mass index (25.0±3.9 kg/m2 vs.24.0±3.5 kg/m2, p＜0.001) than males. Considering cardiovascular risk factors proposed by ATP II, among the 120 subjects receiving lipid-lowering drugs, 72 subjects did not reach the goal of management with the mean difference of LDLC standard of 40.3 ±32.8mg/dI. Conclusions: In conclusion, females in I-Lan county had higher levels of TCHO than males, but insignificant in LDL-C. Only 37.2% of the hyperlipidemia subjects who received lipid-lowering drug have reached the ideal LDL-C levels when their cardiovascular risks were considered, which deservesfurther effort to improve. (Full text in Chinese)

關鍵字

膽固醇 ； 三酸甘油酯 ； 血脂異常 ； 心臟血管疾病 ； 社區醫學 ； 高密度脂蛋白膽固醇

並列摘要

Background: Dyslipidemia is a major risk factor for cardiovascular diseases, and it is particularly true in the middle-aged and elderly. Prevalence of dyslipidemia in Taiwan was mostly described by hospital-based evaluations, community-based investigations regarding to dyslipidemia were relatively lacking. The purpose of this study isto explore the prevalence of dyslipidemia among residents in I-Lan county, and the quality of dyslipidemia management is also evaluated. Material and Methods: People aged over 40 residing in 3 townships of I-Lan county were randomly enrolled into study. Each subject has received serial physical examinations, history taking, anthropometric measurements and laboratory survey by well-trained research staff. Blood biochemistry tests including serum total cholesterol (TCHO), triglycerides (TG) and high-density lipoprotein cholesterol (HDL-C) were measured. Serum low-density lipoprotein cholesterol (LDL-C) were calculate according to Friedewald Formulator. Quality of dyslipidemia management was evaluated on the basis of Adult Treatment Panel Il(ATP II) and related regulations of National Health Insurance Bureau, Taiwan. Results: In total, 1069 subjects were enrolled with the mean age of 64.4±11.3 years and female predominance (55.6% vs. 44.4%). The mean TCHO and TG of the whole subjects were 208.5±40.6 mg/dl, and 130.7±87.7 mg/dI, respectively. Among them, 920 subjects have their HDL-C levels tested. The mean DHL-C and LDLC levels were 46.3±15.6 mg/dI and 135.7±37.3 mg/ dl, respectively. In our study, females had significantly higher TCHO (214.5±42.0 mg/dI vs. 200.8±37.4 mg/ dl, p＜O.OO1), higher HDL-C (48.3±17.3 mg/dl vs. 43.8±17.5 mg/dI, p＜O.OO1), and higher body mass index (25.0±3.9 kg/m2 vs.24.0±3.5 kg/m2, p＜0.001) than males. Considering cardiovascular risk factors proposed by ATP II, among the 120 subjects receiving lipid-lowering drugs, 72 subjects did not reach the goal of management with the mean difference of LDLC standard of 40.3 ±32.8mg/dI. Conclusions: In conclusion, females in I-Lan county had higher levels of TCHO than males, but insignificant in LDL-C. Only 37.2% of the hyperlipidemia subjects who received lipid-lowering drug have reached the ideal LDL-C levels when their cardiovascular risks were considered, which deservesfurther effort to improve. (Full text in Chinese)

並列關鍵字

cardiovascular disease ； cholesterol ； community medicine ； dyslipidemia ； triglyceride ； high-density lipoprotein cholesterol