Chemotherapy and Radiotherapy in Gastric Cancer

胃癌的化學治療與放射線治療

鄭企峰(Chi-Feng Cheng) ； 張意恆(Ian-Y Chang) ； 林哲斌(Che-Pin Lin)

《北市醫學雜誌》 3卷6期 (2006/06) Pp. 581-589

https://doi.org/10.6200/TCMJ.2006.3.6.06

摘要

雖然胃癌的發生率逐年下降，但是胃癌的死亡率仍然相當高。雖然復發的機會相當高，外科手術仍然是唯一的治癒方式。要如何降低術後的復發機率是一重要的研究方向，包括術前及術後的化學治療與放射治療或者兩者合併使用。目前的臨床實驗結果顯示，術後的化學放射治療對於存活率有明顯的提升。對於轉移行性的胃癌，以傳統的化學治療其預後相當差。隨著新一代的化學治療藥物的出現，在治療的反應率有些微的提升，但是病患的平均存活時間仍然少於一年。化學治療合併新的治療方式，如標靶治療，希望能有效的提升病患的平均存活時間。

關鍵字

胃癌 ； 放射治療 ； 化學治療

並列摘要

Although the incidence of gastric cancer has decreased since 1930, it continues to be a significant health problem. Surgical resection is the mainstay treatment of resectable gastric adenocarcinoma. Although the survival rate of patients with early gastric cancer is high, these patients are less than 20% of all gastric cancer patients. The prognosis of locally advanced or metastatic disease is poor. Several recent clinical studies have proven the efficacy of chemotherapy or chemo-radiotherapy in gastric cancer. Despite chemotherapy in metastastic gastric cancer is essentially palliative, several randomized trials have shown that chemotherapy confers a survival advantage. The randomized trial (INT016) of post operative chemo-radiotherapy in patients with localized advanced gastric cancer showed promising result. Another research direction of gastric cancer is preoperative radiotherapy or chemoradiotherapy, and the results of several clinical trials showed the increasing resectable rate and survival benefit. However, there was no strong evidence of post operative chemotherapy in treatment of resectable gastric cancer.

並列關鍵字

gastric cancer ； radiotherapy ； chemotherapy