- 期刊
Pulse Spectrum Analysis in Primary Hypertension Patients
原發性高血壓患者脈波頻譜之分析
摘要
目的：寸口把脈是傳統中國醫學臨床上非常流行且非侵入性的方法，本研究之目的正是探討將寸口把脈作為診斷的可行性。方法：從醫院進行健康檢查的病患之中選取110位疑似原發性高血壓病患進行研究，以5個脈波頻譜指標作為原發性高血壓的脈診指標，分析這五項脈診指標與現代醫學各項健康檢查（各項健康檢查包括血壓、心跳速率、心電圖、常規血液檢查、常規尿液檢查、X光、超音波）以及過去疾病史的相關性，這五項脈診指標分別為(1)第一諧波強度≧2且第四諧波強度≦-3，或第四諧波相位角≦-2；(2)第0諧波強度≧4且第四諧波強度≦-2；(3)第0諧波強度≧4且第三諧波強度及相位角≦-2；(4)第0諧波強度≧4且第三諧波強度≦-2，且第五諧波強度≦-3；(5)第三諧波強度及相位角≦-2，且第六諧波強度及相位角≦-2。第一諧波（肝）之強度每高於正常值的5%則定量為一個”+”，反之每低於正常值的5%則定量為一個”-”；第三諧波（脾）、第四諧波（肺）、第六諧波（膽）之強度每高於正常值的10%則分別定量為一個”+”，反之每低於正常值的10%則分別定量為一個”-”；至於相位部分，所有諧波之壓力波傳送速度每低於正常值的10%則分別定量為一個”-”。結果：當不考慮”+”、”-”的變化量而僅考量”+”、”N”及”-”三種情況，那麼11個諧波總共可產生311（強度）×311（相位）＝177,147×177,147個脈波頻譜，本研究僅選用6個脈波頻譜作為肝異常之指標，卻得到非常高之相關性，p值小於0.001，Kappa值等於0.701。結論：這個結果顯示脈搏諧波頻譜在循環系統具有生理與病理上的重要性，值得進一步去深入研究。
並列摘要
Background and Purpose: Arterial pulse diagnosis is noninvasive and it is very popular in traditional Chinese medicine clinics. The aim of this study was to evaluate the possibility of using pulse diagnosis in patients with the primary hypertension. Methods: Noninvasive analyses of radial pulses were taken in primary hypertension patients immediately after their arrival at the physical examination room. They then underwent physical health examinations including measurement of blood pressure and heart rate, EKG, blood test, urine test, x-ray, ultrasound scanning, and recording medical history. We carried out pulse spectrum analysis on 110 patients with possible primary hypertension. We used five criteria for pulse diagnosis of blood pressure abnormalities to test for correlation. These were (1) C1≧2 (in intensity) and C4≦-3 (in intensity) or C4≦-2 (in phase), (2) C0≧4 (in intensity) and C4≦-2 (in intensity), (3) C0≧4 (in intensity) and C3≦-2 (in intensity) and C3≦-2 (in phase), (4) C0≧4 (in intensity) and C3≦-2 (in intensity) and C5≦-3 (in intensity), (5) C3≦-2 (in intensity and phase) and C6≦-2 (in intensity and phase). For the intensity, C1 (liver) every 5% above normal was given one ”+”, every 5% below normal was given one ”-”. For C3 (spleen), C4 (lung), C6 (gallbladder), every 10% above normal was given one ”+”, every 10% below normal was given one ”-”. For the phase, every 10% delay in the traveling speed of the pressure wave was given one ”-”. Results: Only the ”+”, ”N” (N = normal) and ”-” states were considered, while quantities of ”+” ”-” were not monitored. In the pulse analysis, there were 311 (from intensity) × 311 (from phase) = 177, 147 × 177, 147 possible states (3 qualitative states and 11 harmonics). We considered only five criteria for blood pressure abnormalities and the correlation was very high, p＜0.001, Kappa = 0.701. Conclusion: The results strongly suggested that each harmonic of pulse spectrum has physiological and pathological importance in the circulation and it is worth further study.