基礎胰島素治療第2型糖尿病人之糖化血色素和體重的變化

The Effects of Basal Insulin Treatment on Type 2 Diabetic Patients as Assessed by HbA1c and Body Weight

施李碧玉(Pi-Yu Shih Lee) ； 張美智(Mei-Chi Chang) ； 張伶祝(Lin-Chu Chang) ； 洪建德(Chien-Te Hung)

《北市醫學雜誌》 9卷3期 (2012/09) Pp. 205-213

https://doi.org/10.6200/TCMJ.2012.9.3.02

摘要

Objective: Type 2 diabetes mellitus (DM) is a chronic disease characterized by abnormal carbohydrate metabolism and in general requires long-term intensive glycemic control. Parenteral insulin treatment can promptly bring about well-controlled blood glucose. However, most patients are concerned about an elevation in their body weight and therefore decline the basal insulin treatment. The purpose of this study is aimed at exploring the well-being of patients by examining improvements in glycosylated hemoglobin (HbA1c) and changes in body weight after one year of basal insulin treatment. Methods: The study was carried out at a Metabolic Clinic at Taipei City Hospital from January to May, 2008. Study subjects were type 2 DM patients who routinely visiting the clinic and received complete follow-up studies over a one-year period. Clinic data and demographic data were collected including sex, age and education level. After one year of basal insulin treatment, any changes in HbA1c and body weight were recorded and statistically analyzed using the paired t-test. Results: In total, 323 patients participated in this study, of which 155 were male and 168 were female. The average of age of the patients was 63.7 years. The average HbA1c was 8.8%, and the average of body weight was 65.2 kg. After one year of basal insulin treatment, the HbA1c value had dropped on average by 0.56% and body weight had increased on average by 1.48 kg; both values were statistically significant (p＜0.0001). Conclusion: Among type 2 diabetic patients who have been treated with basal insulin for a whole year, it was found that HbA1c was significantly improved, while body weight had increased. In light of these finding, it seem that it would be beneficial to patients if their anxiety with respect to body weight elevation was mitigated.

關鍵字

糖尿病 ； 基礎胰島素 ； 糖化血色素 ； 體重

並列摘要

Objective: Type 2 diabetes mellitus (DM) is a chronic disease characterized by abnormal carbohydrate metabolism and in general requires long-term intensive glycemic control. Parenteral insulin treatment can promptly bring about well-controlled blood glucose. However, most patients are concerned about an elevation in their body weight and therefore decline the basal insulin treatment. The purpose of this study is aimed at exploring the well-being of patients by examining improvements in glycosylated hemoglobin (HbA1c) and changes in body weight after one year of basal insulin treatment. Methods: The study was carried out at a Metabolic Clinic at Taipei City Hospital from January to May, 2008. Study subjects were type 2 DM patients who routinely visiting the clinic and received complete follow-up studies over a one-year period. Clinic data and demographic data were collected including sex, age and education level. After one year of basal insulin treatment, any changes in HbA1c and body weight were recorded and statistically analyzed using the paired t-test. Results: In total, 323 patients participated in this study, of which 155 were male and 168 were female. The average of age of the patients was 63.7 years. The average HbA1c was 8.8%, and the average of body weight was 65.2 kg. After one year of basal insulin treatment, the HbA1c value had dropped on average by 0.56% and body weight had increased on average by 1.48 kg; both values were statistically significant (p＜0.0001). Conclusion: Among type 2 diabetic patients who have been treated with basal insulin for a whole year, it was found that HbA1c was significantly improved, while body weight had increased. In light of these finding, it seem that it would be beneficial to patients if their anxiety with respect to body weight elevation was mitigated.

並列關鍵字

diabetes mellitus ； DM ； basal insulin ； glycosylated hemoglobin ； HbA1c ； body weight