心包脂肪組織與代謝症候群之相關性

Association between Pericardial Adipose Tissue and Metabolic Syndrome

吳欣潔(Hsin-Chieh Wu) ； 陳建志(Chien-Chih Chen) ； 吳岱穎(Tai-Yin Wu) ； 郭冠良(Kuan-Liang Kuo) ； 陳哲民(Che-Min Chen)

《北市醫學雜誌》 12卷4期 (2015/12) Pp. 308-321

https://doi.org/10.6200/TCMJ.2015.12.4.03

摘要

目的：心包脂肪組織與許多肥胖指標密切相關，也是一個預測內臟脂肪多寡的指標。本研究目的在探討心包脂肪組織與代謝症候群的關聯性。方法：本研究收集2008年至2014年間，於台北市某區域醫院健檢族群中，胸部X光上發現心包脂肪組織的受檢者（個案組），並以1:3的配對方式，找出相同性別、年齡相仿且接受健檢時間相近但胸部X光上沒有心包脂肪組織的對照組，並追蹤兩組後續約兩年後的健檢結果。分析這些受檢者在一開始與追蹤時的代謝症候群相關因子。結果：個案組在一開始的平均體重（p ＜0.01）、腰圍（p ＜0.01）、身體質量指數（p ＜0.01）、空腹血糖平均值（p =0.04）及三酸甘油酯平均值（p =0.04），皆顯著高於對照組；高密度脂蛋白膽固醇平均值顯著低於對照組（p =0.04）；而個案組的代謝症候群盛行率亦顯著較高（p ＜0.01）。後續追蹤發現，個案組的身體質量指數（p =0.02）及空腹血糖平均值（p ＜0.01），顯著高於對照組；且個案組的代謝症候群盛行率亦顯著較高（p ＜0.01）。同時，在所有完整追蹤的受檢者中，個案組及對照組追蹤後新發生代謝症候群的發生率分別為16.7% 及9.4%（p =0.45）。結論：在無症狀的健檢族群中，胸部X光有呈現心包脂肪組織的受檢者代謝症候群的盛行率較高。

關鍵字

心包脂肪組織 ； 代謝症候群 ； 健檢受檢者 ； 預防醫學

並列摘要

Objective: Pericardial adipose tissue is associated with several obesity-related parameters. It is also an indicator to predict visceral fat. We aimed to investigate the relationship between pericardial adipose tissue and metabolic syndrome. Methods: We enrolled health examinees who had chest radiograms between 2008 and 2014 in a regional hospital in Taipei City and with pericardial adipose tissue presented on the radiograms (case group). Matched in a 1:3 fashion, we recruited subjects with the same gender, similar age and close health exam dates but without pericardial adipose tissue on chest radiograms as control. We followed up subsequent health examination results of the research subjects about two years later, and analyzed the metabolic syndrome parameters at baseline and follow-up, including body height, body weight, waist circumference, body mass index, blood pressure, fasting blood glucose, total cholesterol, triglyceride, high- and low-density lipoprotein cholesterol levels. Results: The case group had significantly higher values of mean body weight (p＜0.01), waist circumference (p＜0.01), body mass index (p＜0.01), fasting glucose (p=0.04) and triglyceride (p=0.04) and significantly lower values of high-density lipoproteincholesterol (p=0.04) than control group at baseline. The prevalence of metabolic syndrome was also significantly higher in case group (p＜0.01). In subsequent follow-up, the case group had significantly higher values of body mass index (p=0.02) and fasting glucose (p＜0.01); the prevalence of metabolic syndrome was also significantly higher in case group (p＜0.01). According to the analysis of complete cases, the prevalence of newly-diagnosed metabolic syndrome was 16.7% in case group and 9.4% in control group (p=0.45). Conclusion: In asymptomatic health examinees, the prevalence of metabolic syndrome was higher in those with pericardial adipose tissue.

並列關鍵字

pericardial adipose tissue ； metabolic syndrome ； health examinees ； preventive medicine