非酒精性脂肪性肝病之診斷與治療

Diagnosis and Treatment of Nonalcoholic Fatty Liver Disease

張力仁(Li-Jen Chang)

《北市醫學雜誌》 16卷2期 (2019/06) Pp. 97-106

https://doi.org/10.6200/TCMJ.201906_16(2).0001

摘要

非酒精性脂肪性肝病是全球常見肝病之一，在台灣亦是一項攸關國人健康與公共衛生的問題。非酒精性脂肪性肝病包括單純性脂肪變性，逐漸發展成進行性脂肪變性、肝炎、纖維化、肝硬化，或肝癌。由於非酒精性脂肪性肝病與代謝症候群和第二型糖尿病具高度之關聯性，病人並可能發生併發症或發展為晚期肝纖維化與非酒精性脂肪性肝炎等風險。在本綜述中，我們關注於非酒精性脂肪性肝病之流行病學、風險因素、診斷、藥物及其他非藥物治療。

關鍵字

非酒精性脂肪性肝病 ； 糖尿病 ； 診斷 ； 治療

並列摘要

The prevalence of non-alcoholic fatty liver disease (NAFLD), the most common type of liver disease, is increasing worldwide and has been recognized as a public health problem in Taiwan. NAFLD encompasses simple steatosis to more progressive steatosis with associated hepatitis, fibrosis, cirrhosis, and in some cases, hepatocellular carcinoma. Since NAFLD is strongly associated with metabolic syndrome and type 2 diabetes mellitus, the patients may have increased risk of complications or progressing to advanced fibrosis and nonalcoholic steatohepatitis. In this review, we focus on the epidemiology, risk factors, diagnosis, and medications, and how NAFLD may be improved.

並列關鍵字

nonalcoholic fatty liver disease ； diabetes ； diagnosis ； treatment