評估不可磨粉藥品對簡易懸濁法的適用性

目的：評估院內不可磨粉的藥品是否可以以簡易懸濁法而崩解懸浮。方法：本研究期間為2020年7月至2021年5月收集某醫院院內不可管灌的藥品，且排除公費、管制藥品、臨採以及單價（健保價）高於100元／顆藥品。每項藥品皆準備3顆進行（一）崩解懸浮測試（Decay-suspension test）。（二）鼻胃管通過測試（Test for tube passage）。所有測試皆於室溫（25.8±0.48°C）、相對恆定濕度（64.0±6.98%），以及照度（1070.4±49.5 Lux）下進行。最後將適用於簡易懸濁法之院內不可磨粉藥品進行分析，可改善不適合磨粉藥品卻磨粉給管灌病人使用的機率。結果：本院口服藥品總共有560項，當中不適合磨粉藥品有169項，經排除納入之藥品，最後納入本研究總共有44項藥品進行簡易懸濁法的測試，研究發現44項不可磨粉的藥品中，有14項（31.8%）藥品適用簡易懸濁法，此14項藥品，有13項（除Atozet外）於室溫放置5分鐘內震搖即可完全崩解。結論：此研究是針對不可磨粉的藥品，但因藥品本身的特性，成功率會偏低，但仍有31.8%藥品適用簡易懸濁法，並可降低不適合磨粉藥品卻磨粉給管灌病人使用的機率。

關鍵字

不可磨粉的藥品；簡易懸濁法；崩解懸浮測試；鼻胃管通過測試

並列摘要

Objective: To evaluate whether non-crushable drugs available in our hospital can be disintegrated and suspended using a simple suspension method. Methods: Non-crushable drugs of our hospital, excluding publicly funded, controlled, and casually procured drugs, as well as those with a unit price (health insurance price) >100 dollars, were collected from July 2020 to May 2021. Three tablets of each drug were prepared for decay-suspension and tube passage tests. All tests were performed at room temperature (25.8 ± 0.48°C), and at consistent relative humidity (64.0 ± 6.98%) and illumination (1070.4 ± 49.5 Lux). We aimed to identify non-crushable drugs that suit the simple suspension method to avoid administering non-suspensible drugs via nasogastric tube feeding. Results: There were 560 oral drugs in our hospital. Among the 169 non-crushable drugs, 44 met the inclusion criteria for a simple suspension experiment. Among the 44 non-crushable drugs, 14 (31.8%) were suitable for the simple suspension method in which 13 (except Atozet) disintegrate after shaking at room temperature for 5 min. Conclusion: This study considered the suitability of suspending non-crushable drugs using a simple suspension method. The suspension success rate was relatively low due to the drug characteristics. Still, the simple suspension method suits 31.8% of the drugs, thus reducing the chance of grinding and nasogastric tube feeding of the drugs unsuitable for suspension.

並列關鍵字

non-crushable drugs ； simple suspension method ； decay-suspension test ； tube administration test

參考文獻

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