Even under various environmental conditions, weeds are an unavoidable threat to agricultural ecosystem and agricultural biodiversity. Weeds are widely dispersed around the globe through natural forces and human culture becoming exotic plants and/or invasive weeds of farmland. In the current modes of human activities and fossil energy use, trend of climate change is projected to continue and will bring profound effects and consequences to socio-economic status, biosystems, and agricultural production including weed management. New environmental scenarios give rise to a rapid changes of climate would further deteriorate and complicate the negative impacts of weeds, while highlighting the importance and significance of dynamically adapting and adjusting weed management strategies to cope with climate change.