Psycho-mental disease is a complex disorder featured by abnormal recognition, emotion, awareness and behavior. These abnormalities including annoyance, panic, depression, delirium, dementia dimly, restlessness, anxiety ,insomnia, dream fullness, chest-costal discomfort, palpitation, dizziness, short of breath, tendon and muscle twitching, thermal sensation abnormally and menstrual irregularity. We'll investigate these abnormalities in mental and physical aspects and classify those symptoms as follows: 1) liver Qi jammed, feeling restless. 2) heart-kidney deficiency. Qi jammed and blood stasis. 3) heart-spleen deficiency, dampness and blocked. 4) liver jammed and spleen deficiency, feeling restless. From psycho-mental patients of Provincial brain hospital and OPD of Nanjing university of TCM, we classify them as above symptoms and evaluate the effect of treatment with traditional Chinese medicine through drug-giving environment and drug-using obedience.