Based on the characteristics of 750 movies released from 2006 through 2010, this study intends to explore the successful factors of American cinemas by applying regression analysis on three categories of box offices: first- day, first week, and nationwide box office in the United States. The results show that different factors influence these three categories of box offices: big film makers with strong marketing power and channels (number of theaters) would better payoff than others, whereas remake-films do not gain revenue as high as expected. Besides, the effects of first week box office and audience's word of mouth (referral) on total sales deserve film makers' attention. Several managerial implications are also provided.