The present study proposed several scenario simulations of flood disaster based on the previous researches and historical flood events in Nantou County. We employed a 2D numerical model (FLO-2D) which can compute the velocity and depth on the two dimensional actual terrain to simulate floods. Meanwhile, the calculated data are used to estimate the possible damage of flood disaster. The results also can be the reference for the disaster prevention. This study selected 3 cases including Mao-Luo Creek, Dong-Pu-Rui Creek and Jun-Keng Creek watersheds, which were simulated and used 500mm rainfall for a day as the simulated condition. Besides, the flood disaster loss was estimated by these results of simulations. The estimation method is suggested by Water Resources Agency. Finally, the conclusions and perspectives are presented.