- 期刊
以雙能量X光骨質密度儀評估生產胎數對於骨質密度的影響
Evaluation of Bone Mineral Density in Multiparous Postmenopausal Women by using dual-energy x-ray Absorptiometry
摘要
Estrogen deficient and calcium metabolism disorder have been proposed as a risk factor for the development of osteoporosis. Most osteoporotic fracture occurs in the group of postmenopausal women with low estrogen level. However, during pregnancy the fetus takes approximately 30 g of calcium from the mother for skeleton development. The associated insufficient estrogen during pregnancy may lead to bone mineral loss. The aim of tjis study was to evaluate the influence of multiple pregnancies on the bone mineral density (BMD) in the postmenopausal women. The study included 141 post-menopausal women (range 50~85 years) who had more than one year menopause history and at least two pregnancies and breastfeeding experience. Lumbar spine and femoral neck bone mineral density (BMD, g/cm^2) was measured using dual energy x-ray absorptiometry (Lunar DPX-L, Madison, WI). The subjects were divided into three age groups (range 50~59, range 60~69, over 69) and BMD data are adjusted for differences in the number of pregnancy (range 2~5). BMD decreased significantly with increasing the number of deliveries in the group of 50~69 years, but not so in the group of age over 69 years. Peak BMD of lumbar spine (1.124 g/cm^2, p=0.001) and hip (0.850 g/cm^2, p=0.007) occurred in the group of 50-59 years with two deliveries. In addition, lowest BMD of lumbar spine (0.847 g/cm^2, p＜0.05) and hip (0.649 g/cm^2, p＜0.05) was presented in the age over 69 with over 5 deliveries. BMD was significantly lower for lumbar spine (16%) and hip (6%) in women with age of 50-59 and with over 5 deliveries in comparison with women with two deliveries. These findings indicated that BMD were significantly decreased with increasing age and number of pregnancies. We concluded that pregnancies and lactation could be used as risk factors for future osteoporosis.
並列摘要
Estrogen deficient and calcium metabolism disorder have been proposed as a risk factor for the development of osteoporosis. Most osteoporotic fracture occurs in the group of postmenopausal women with low estrogen level. However, during pregnancy the fetus takes approximately 30 g of calcium from the mother for skeleton development. The associated insufficient estrogen during pregnancy may lead to bone mineral loss. The aim of tjis study was to evaluate the influence of multiple pregnancies on the bone mineral density (BMD) in the postmenopausal women. The study included 141 post-menopausal women (range 50~85 years) who had more than one year menopause history and at least two pregnancies and breastfeeding experience. Lumbar spine and femoral neck bone mineral density (BMD, g/cm^2) was measured using dual energy x-ray absorptiometry (Lunar DPX-L, Madison, WI). The subjects were divided into three age groups (range 50~59, range 60~69, over 69) and BMD data are adjusted for differences in the number of pregnancy (range 2~5). BMD decreased significantly with increasing the number of deliveries in the group of 50~69 years, but not so in the group of age over 69 years. Peak BMD of lumbar spine (1.124 g/cm^2, p=0.001) and hip (0.850 g/cm^2, p=0.007) occurred in the group of 50-59 years with two deliveries. In addition, lowest BMD of lumbar spine (0.847 g/cm^2, p＜0.05) and hip (0.649 g/cm^2, p＜0.05) was presented in the age over 69 with over 5 deliveries. BMD was significantly lower for lumbar spine (16%) and hip (6%) in women with age of 50-59 and with over 5 deliveries in comparison with women with two deliveries. These findings indicated that BMD were significantly decreased with increasing age and number of pregnancies. We concluded that pregnancies and lactation could be used as risk factors for future osteoporosis.
延伸閱讀
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