As the elderly population increased, the prevalence of chronic wounds has become an important public health issue. The acquisition, understanding, and use of wound care information are important for the chronic wound healing. This ability to acquire, understand, and respond to healthcare information is health literacy. To care chronic wound patients with low health literacy, it is very important to improve the low health literacy problem, which the health care professionals should pay attention to. There is a lack of articles on this subject. Through the literature review, this article aims to understand the definition of low health literacy and chronic wounds, the model of health literacy, and the pathophysiology of chronic wounds, clinical assessment and practice. It can make health caregivers know how to identify, evaluate, and care chronic wound patients with low health literacy and to improve the patients' health literacy, that promotes wound healing and prevents recurrence.